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There were 44 patients with New YorkHeart Association (NYHA) class III symptoms due to iPAHand hPAH in this study.
A review of 13 randomised controlled tri-als of treatment of established RDS with animal-derived surfactant showed a signi? cant decreasein the risk of any air leak (RR 0.47, 95 % CI0.39, 0.58), pneumothorax (RR 0.42, 95 % CI0.34, 0.52), pulmonary interstitial emphysema(RR 0.45, 95 % CI 0.37, 0.55), neonatal mortal-ity (RR 0.68, 95 % CI 0.57, 0.82), risk of mor-tality prior to hospital discharge (RR 0.63, 95 %CI 0.44, 0.90) and BPD or death at 28 days ofage (RR 0.83, 95 % CI 0.77, 0.90). Cerebral microdialysis has beenshown to reliably predict the onset of ischemia, particularly with enough warning to enableimplementation of a variety of interventions directed toward limiting permanent injury. Survival in primary pulmonary hypertension:the impact of epoprostenol therapy
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