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This iscertainly true of intra-familial abuse (Rogers and Terry 1984) although there is some evidence thatboys may be at greater risk from stranger-perpetrators (Abel et al. In another qualitative investigation,Miller and colleagues (2006) explored the psychosocial impact of dysphagia in patientswith Parkinson’s disease. Anhypothesis to conceal these apparently con?icting evidences may be proposed con-sidering that mutant p53 may block TGF-beta induced cell cycle arrest, senescenceor apoptosis, which require full activation of transcriptionally active SMAD com-plexes able to increase the expression of p21 and PAI-1, while simultaneously pro-viding a novel mechanism of aggressiveness based on sequestration of p63 in aternary complex with phosphor-SMADs.
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